Research & Innovation
Integrating clinical-trial evidence, causal machine learning, and AI to individualize treatment selection, procedural strategy, and systems of care in acute ischemic stroke.
Counterfactual / CATE machine-learning models for individualized EVT decisions.
PMID 41603297AI triage across a 60-spoke network; the LUCID clinical decision-support platform.
Pitt InventionPrimary Manager & Co-Investigator of the multicenter DUSK Trial; roles in BOLT and tenecteplase time-window studies.
DUSK TrialCEO of HORUS NeuroTechnologies (Pitt-licensed); provisional patents for an intracranial stent and an AI-powered stroke decision-support platform.
TechnologyLandmark meta-analyses: VERITAS (Lancet), ATLAS-ER (Annals), IVT in minor stroke (Neurology).
GBD collaborator: stroke & neurological burden in Lancet Neurology, JAMA Neurology, and Lancet Global Health.
Publications
Between-Study Heterogeneity in Extended-Window IV Thrombolysis for Acute Ischemic Stroke: Meta-Analysis of 18 RCTs
Neurology. 2026;107(3):e218331
Impact of an AI-Driven Triage System on Workflow and Transfer Efficiency: 4,548 Admissions Across Four Hubs and Sixty Spokes
J Neurol Neurosurg Psychiatry. 2026;97(7):620-629
Individualized Treatment in DMVO Stroke Using a Validated Explainable Counterfactual Treatment-Estimation Model
Annals of Neurology. 2026;99(5):1198–1209
Direct Transport to a Thrombectomy Center Accelerates Reperfusion Therapies in Nonurban Settings
J Am Heart Assoc. 2026;15(1):e044213
Association of Anesthesia Strategies with Outcomes in EVT for DMVO: MR CLEAN Registry & Meta-analysis
European Stroke Journal. 2026
ATLAS-ER: Adjunctive Thrombolytics After Successful Endovascular Reperfusion, Meta-Analysis of RCTs
Annals of Neurology. 2025;98(6):1299–1314
Balloon Guide Catheter Impact on Angiographic and Clinical Outcomes in DMVO Stroke Thrombectomy
J NeuroInterventional Surgery. 2025
Direct Endovascular vs Bridging Therapy in M2-Segment Occlusion: MR CLEAN Registry (IPTW)
Stroke. 2025;56(10):2866–2878
Meta-Analysis of RCTs on IV Thrombolysis in Minor Acute Ischemic Stroke
Neurology. 2025;105(3):e213863
VERITAS: Endovascular Therapy for Acute Vertebrobasilar Occlusion, IPD Meta-Analysis
The Lancet. 2025;405(10472):61–69
IV Thrombolysis Prior to EVT in Basilar-Artery Occlusion: Pooled Analysis of Four RCTs
Cardiovasc Intervent Radiol. 2025;48(12):1869–1877
Global Burden of Nontraumatic Subarachnoid Hemorrhage: GBD 2021
JAMA Neurology. 2025;82(8):765–787
Global Burden of Stroke and Its Risk Factors, 1990–2021: GBD 2021
Lancet Neurology. 2024;23(10):973–1003
Global Burden of Disorders Affecting the Nervous System, 1990–2021: GBD 2021
Lancet Neurology. 2024;23(4):344–381
Mode of Onset Modifies the Effect of Time to EVT: DAWN Trial Analysis
Annals of Neurology. 2024;96(2):356–364
DMVO Strokes: Understanding the Present and Paving the Way for a Better Future
Journal of Stroke. 2024;26(2):190–202
Higher Procedural Volumes Are Associated with Better Outcomes in EVT
Annals of Neurology. 2023
From Therapeutic Nihilism to Armamentarium: Meta-analysis of EVT RCTs in Large-Core Stroke
Interventional Neuroradiology. 2023
Neurological Events Reported After COVID-19 Vaccines: VAERS Analysis
Annals of Neurology. 2022;91(6):756–771
Direct to Angiosuite vs Conventional Imaging in Suspected LVO: Meta-Analysis
Stroke. 2022;53(8):2478–2487
Association Between Helicobacter pylori Infection and Stroke: Meta-Analysis of 273,135 Patients
Journal of Neurology. 2020